Hollow perovskite oxide La0.5Sr0.5MnO3 nanospheres are synthesized by using carbon spheres as template in the presence of citric acid. Among the samples investigated in this work, the one obtained at a sintering temperature of 700 degrees C exhibits the highest catalytic activity in the oxygen reduction reaction (ORR) in an alkaline electrolyte. The electrochemical measurement data shows that the sample has a positive onset potential (0.860 V) and a high limiting current density (6.48 mA cm(-2)). Furthermore, the catalyst shows a high selectivity towards methanol and a better stability than a commercial Pt/C catalyst. The hollow La(0.5)Sr(0.5)MnO(3 )nanoshperes described in this manuscript hold a great promise for applications in metal-air batteries and alkaline fuel cells. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.