Many applications use hydrogen addition and high-pressure fuel injection technology to improve combustion performance. In this study, spray atomization and combustion characteristics of a diesel fuel jet, under the injection pressure of 350 MPa, injecting into a constant volume combustion vessel filled with air-hydrogen mixture at the diesel engine relevant condition are investigated by simulation method. A simplified mechanism of the n-heptane (C7H16) oxidation chemistry mechanism consisting of 26 reactions and 25 species integrated with the Keromnes-2013 hydrogen combustion mechanism and EDC combustion model are utilized to predict the diesel fuel spray auto-ignition and combustion. The ambient gas is the mixture of air and hydrogen range in volume fraction from 0% to 10%. The ambient temperature and pressure is set to 1000 K and 3.5 MPa, respectively. The results indicate that as the hydrogen volume fraction is 2%, the minimum overall droplet SMD (Sauter Mean Diameter) is approximately 0.95 mm, which is obviously smaller than that of the case with the conventional high injection pressure. In cases that H-2 v/v% larger than 4%, the maximum gaseous temperature increased significantly up to 2700 K. There are two peaks in the temperature growth rate curves as the hydrogen fraction of 8% and 10%. The high temperature at the outer edge of the spray is clearly seen due to its high value when the hydrogen fraction is larger than 4%. The hot reaction layer is the main location of CO formation. The H, OH radicals are formed at the edge of the spray where the temperature is high. The hydrogen species obviously promotes the oxidation and combustion of diesel fuel. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.