Metal-organic frameworks (MOFs) are a new class of functional materials having porous structures that show extraordinary specific surface areas, and tunable surface chemistry; hence, they hold great potential as photocatalysts. This review describes the fundamentals of MOFs and possible new research directions in the area of heterogeneous MOFs that can provide enhanced photocatalytic performance, especially for hydrogen production, degradation of emerging organic pollutants, and CO2 reduction. The role of MOFs as multifunctional photocatalysts for light-stimulated organic reactions through an effective combination of metal/ligand/guest-based photocatalysts is discussed. Recent literature is discussed critically on the design and selection of materials, with possible directions to improve their catalytic properties. Furthermore, this comprehensive review systematically discusses the current developments of various MOFs-based hybrid nanostructures as multifunctional photocatalysts from different points, including several synthetic methodologies, key features, photocatalytic mechanism, and various influencing parameters to enhance catalytic efficiency. The recent achievements are critically discussed in the designing and selection of MOFs-based functional materials, with directions to effectively improve their catalytic properties for various photocatalytic applications. The article also summarizes with challenges and future prospects for the cost-effective and large scale photocatalytic applications of MOFs-based heterostructured catalysts. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.