Exploring efficient, abundant, low-cost and stable materials for hydrogen evolution reaction (HER) is highly desired but still a challenging task. Herein, Ni-Se-Mo electrocatalysts supported on nickel foam (NF) substrate were synthesized by a facile one-step electrode position method. The Ni-Se-Mo film presents high electrocatalytic activity and stability toward HER, with a low overpotential of 101 mV to afford a current density of 10 mA cm(-2) in 1.0 M KOH medium. Such excellent HER performance of Ni-Se-Mo film induced by the synergistic effects from Mo-doped Ni-Se film leads to the fast electron transfer. This work provides the validity of interface engineering strategy in preparing highly efficient transition metal chalcogenides based HER electrocatalysts. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.