The reduction of high concentrations of NOX and SO2 has been studied for the simulation of NOX and SO2 removal from off-gases generated by diesel engines in which heavy fuel oil is usually used. The combination of electron beam (EB) and a wet scrubber method proved to be very promising for this purpose. In this work, we investigated NOX reduction under EB with the application of NaClO, NaClO2, or NaClO3 as an oxidant in two different scrubber solutions, phosphate buffer (Na2HPO4-KH2PO4)-simulated sea water solution and NaOH-simulated sea water solution. The concentration of buffer in the scrubber solution was 5 mM. The concentration of NaOH in the scrubber solution was 7 mM. Compared with the removal performance of NO for the three different oxidants, the application of NaClO2 gave the best removal efficiency. For the inlet concentration of NO gas set at 1000 ppm and the EB dose set at 10.9 kGy, the application of NaClO2 reaches a maximum of 95.03% NO removal efficiency, while the NaClO oxidant reached a maximum of 49.84% removal efficiency and the NaClO3 oxidant reached a maximum of 54.25% removal efficiency. The results show that the chosen series of oxidants have the potential to be applied in the removal of NOX and SO2 from the off-gases of a diesel engine. For example, they could be used on cargo ships, which generate large amounts of NOX and SO2 from the combustion of heavy oil which contains sulphur and nitrogen.