In this paper, novel flower-like hollow MoS2 microspheres (FHMs) were synthesized by a hydrothermal method using MF microspheres as template. The FHMs were hydrophobically modified and utilized as porous fillers to fabricate FHMs/acrylic resin composites through suspension polymerization. The oil-absorption tests revealed that the composite with 4 wt% FHMs had a high oil-absorption capacity, which might be due to the synergistic absorption effect of organic and inorganic components. Their high absorption capacity, rapid absorption rate, and excellent reusability make them attractive options as absorbents for practical oil/water separation.