The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was characterized by X-ray diffraction, field emission scanning electron microscopy, FT-IR spectroscopy, thermal gravimetric analysis, and energy dispersive analysis of X-rays, and inductively coupled plasma-mass spectrometry. This green sulfasalazine drug complex supported on CoFe2O4 cellulose was applied as an efficient and recyclable catalyst for organic reactions such as synthesis of functionalized 4H- pyrans and 1,4-dihydropyridines derivatives. All of the reactions were carried out successfully under mild conditions in a short reaction time. The used catalyst was easily separated and reused for 6 runs without noticeable loss of its catalytic activity. [GRAPHICS] .