In this study, we fabricated ultrafiltration mixed-matrix membranes through wet phase inversion method of cellulose acetate (CA) blended with polydopamine (PDA) particles solution. PDA, as an organic and hydrophilic particle, altered the physicochemical and antifouling property of CA membranes. X-ray photoelectron spectroscopy confirmed the presence of PDA particles on the membrane surface. Adding PDA particles led to the formation of macrovoids onto the cross-sectional morphology of CA membranes. This also improved the membrane porosity, pore size, and hydrophilicity. At an optimum concentration of 0.2 wt% PDA, the membrane presented the highest pure water flux of 771.98 L m(-2) h(-1) at 1 bar and significant oil rejection (93-99%). Furthermore, the modified membrane exhibited better antifouling property (flux recovery = 87%; irreversible fouling = 12%; Reversible fouling = 80%) contrasted to a pristine CA membrane (flux recovery ratio = 70%; irreversible fouling = 25%; reversible fouling = 45%). (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.