The synthesis and design of separation systems for nonideal azeotropic mixtures traditionally utilize graphical methods, focusing on separation feasibility within a sequential design framework. Once promising systems have been identified sequencing and design are optimized in a second stage, limited by the separation feasibility region defined in the first stage. A generalized modular representation proposed for the synthesis of nonideal separations can simultaneously explore entrainer and sequencing alternatives. A multipurpose mass/heat exchange module, introduced in earlier work is employed to investigate separation units and structures as mass- and heat-exchange possibilities. Process units, separation sequences, and entrainers that aid the separation ave examined within one separation problem rather than in a sequential manner. Promising separation schemes can be further considered for detailed design optimization.