In this paper, anew method combines chemical/physical crosslinking, and emulsification-foaming porogenic was adopted to prepare n-hydroxyapatite (n-HA)/polyvinyl akohol (PVA)/chitosan (CS) porous composite hydrogel using artificial cornea scaffold materials. The fabricate conditions, including the type and amount of emulsification-foaming porogen, mixing time and speed etc. were researched. The results showed the optimal condition that the alkylphenol polyoxyethylene ether (OP) acted as emulsification-foaming porogen, with the ratio of W-PVA/W-OP as 3.75, and mixing 15 min with a stirring speed of 800 r.min(-1). Additionally, the fabricated composite hydrogel scaffold materials possessed interconnected internal holes, a moisture content of above 65%, and tensile strength of above 6 MPa. In vitro cytotoxicity and acute systemic toxicity assay confirmed that the scaffolds did not show any cytotoxicity. The as-prepared hydrogel could be a promising candidate for artificial cornea scaffold material. (C) 2019 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.