In the present study, natural convection heat transfer and its associated entropy generation in a porous trapezoidal enclosure saturated with a power-law non-Newtonian fluid has been numerically investigated. Horizontal walls of the enclosure are assumed to be adiabatic while the side walls are considered to be kept at a constant temperature. A continuum-based approach is adapted here to model the fluid flow through porous media and the Darcy's law is modified to account for non-Newtonian rheological behavior of the fluid. The obtained governing equations are discretized using the finite volume method and a detailed parametric study is undertaken to account for the effects of various relevant parameters of the problem on the heat transfer and entropy generation rates. It was shown that the impact of the power-law index on both entropy generation and heat transfer significantly intensifies in a convection-dominated flow regime inside the enclosure, especially for a shear thinning liquid. Moreover, heat transfer rate and entropy generation increase as the sidewall angle is elevated.