A simple and sensitive method for the determination of propranolol using modified screen printed carbon electrode (MSPCE) has been presented. The electrochemical measurements of propranolol are studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CHA). The MSPCE exhibite excellent catalytic activity towards electrochemical oxidation of propranolol in phosphate buffer solution (PBS) of pH 7.0. The MSPCE facilitate the determination of propranolol in the concentration range 0.4 - 200.0 mu M and a detection limit and sensitivity of 80 nM and 0.052 mu A/mu M has been achieved.