The catalytic cracking of 2-methoxy-4-methylphenol (MMP) and of a mixture of this compound (20 wt %) with n-hexadecane (C-16) has been conducted in a CREC Riser Simulator Reactor at 400-550 degrees C using an equilibrium FCC commercial catalyst. The MMP and C-16 have been selected as model compounds of bio-oil and vacuum gasoil (VGO), respectively. The analyses of the conversion and product lump yields (dry gas, LPG, gasoline, and coke) have showed that there were synergistic effects between the reactions of the two feeds. The main synergistic effect is the reduction of the yield of coke with respect to that obtained with the individual feeds, as a consequence of the effect of the hydrogen-transfer reactions and the presence of steam on the coke formation mechanisms. The lower deactivation of the catalyst brings a lower yield of dry gas and a higher of gasoline. As a result of the study using model compounds, it is anticipated that the reduction of the catalyst deactivation is a favorable factor in the upgrading of bio-oil together with VGO in FCC units.