Improvement in the cooling system performance by making the temperature distribution uniform is an essential part in design of polymer electrolyte membrane fuel cells. In this paper, we proposed to use water-CuO nanofluid as the coolant fluid and to fill the flow field in the cooling plates of the fuel cell stack by metal foam. We numerically investigated the effect of using nanofluid at different porosities, pore sizes, and thicknesses of metal foam, on the thermal performance of polymer electrolyte membrane fuel cell. The accuracy of present computations is increased by applying a three-dimensional modeling based on finite-volume method, a variable thermal heat flux as the thermal boundary condition, and a two-phase approach to obtain the distribution of nanoparticles volume fraction. The obtained results indicated that at low Reynolds numbers, the role of nanoparticles in improvement of temperature uniformity is more dominant. Moreover, metal foam can reduce the maximum temperature for about 16.5 K and make the temperature distribution uniform in the cooling channel, whereas increase in the pressure drop is not considerable.