Carvedilol is a drug for the treatment of congestive heart failure whose solubility in solvent and crystallization process are poorly understood. In this study, the solubilities of carvedilol in water, ethanol, acetone, tetrahydrofuran, methyl alcohol, ethyl acetate, (water + ethanol), (water + acetone), and (water + tetrahydrofuran) binary mixtures were measured in the temperature range from 278.15 to 313.15 K under atmospheric pressure by the gravimetric method. The experimental values have indicated that increasing temperature can improve the solubility of carvedilol in all selected binary solvents. To correlate the solubility data of carvedilol, the Buchowski-Ksiazaczak lambda h model was used to fit the solubility data of all pure solvents, while the solubility data of all binary solvent mixtures were fitted by the modified Apelblat equation, general cosolvency model, and Jouyban-Acree model. The results show that the modified Apelblat equation in binary mixed solvents has the lowest mean deviation and can be used as the optimal model for data fitting.