The objective of the present study was to study the solubility of nitazoxanide (NTZ) in 12 organic solvents such as methanol, ethanol, isopropanol, npropanol, 1-butanol, ethyl acetate, toluene, acetonitrile, 1,4-dioxane, N-methyl-2-pyrrolidone (NMP), N,N-dimethylformamide (DMF), and 2-butanone by using the isothermal saturation method over a temperature range of 273.15-313.15 K under 101.3 kPa. Experimental solubility data of NTZ was fitted with the modified Apelblat and lambda h equations. The maximum mole fraction solubility of NTZ was found in NMP (1.127 x 10(-1) at 313.15 K) followed by DMF (1.043 x 10(-1) at 313.15 K), 1,4-dioxane (3.107 x 10(-2) at 313.15 K), 2-butanone (2.286 x 10(-2) at 313.15 K), ethyl acetate (3.99 x 10(-3) at 313.15 K), acetonitrile (2.011 x 10(-3) at 313.15 K), 1-butanol (6.17 x 10(-4) at 313.15 K), isopropanol (5.80 x 10(-4) at 313.15 K), n-propanol (5.25 x 10(-4) at 313.15 K), ethanol (4.50 x 10(-4) at 313.15 K), methanol (3.34 x 10(-4) at 313.15 K), and toluene (2.91 x 10(-4) at 313.15 K). The maximum values of relative average deviation (RAD) and root-mean-square deviation (RMSD) were 4.62% and 9.478 x 10(-4), respectively, and were obtained in 2-butanone with the.h equation. Through the analysis of RAD and RMSD values, it was found that the calculated value of the modified Apelblat equation was closer to the experimental value. The solubility data obtained in the present study could be useful for optimizing the purification process of NTZ.