In this investigation, adsorption heats were determined using a direct method (adsorption calorimetry, Ad-Cal) and an indirect method (in which adsorption isotherms are measured at different levels of pressure and temperature) that makes use of thermodynamics, using the Clausius-Clapeyron (CC) equation, which is able to evaluate the isosteric heat. The results obtained from the two methods were compared determining the adsorption of CH4 on five normal structures of metal-organic frameworks (MOFs) synthesized in this investigation: zeolitic imidazolate framework (ZIF)-8, Hong Kong University of Science and Technology (HKUST)-1, isoreticular MOF (IRMOF)-1, MOF-177, and MgMOF-74, with the intention of establishing the similarities and differences between these methods. The experimental results of adsorption heats were fit at models: Dubinin-Astakhov (DA), and Toth, Unilan modified to determine the extent of each of the methods used in this analysis. This research has found a good agreement between the measured heat using the calorimetric method and model DA throughout the load range of CH4. Also, this study found that the model fits the least data obtained by adsorption calorimetry. The adsorption capacity of CH4 was also analyzed.