The interactions of the drug in aqueous media are associated with many thermodynamic changes. To understand these thermodynamic changes, systematic measurements of density and speed of sound of creatinine in aqueous and in aqueous solutions of 0.06 mol.kg(-1) urea and 0.06 mol.kg(-1) dextrose were carried out at T = 288.15-313.15 K within the concentration range of 0.02-0.2 mol.kg(-1). All measurements were performed for the density (rho) and speed of sound (u) on Anton Paar DSA 5000M instrument. Further, the density data was employed to calculate the apparent molar volume of solute (V phi) and apparent molar volume of transfer (Delta V-tr(phi)0).