The current water treatment technology is still based on low energy efficient processes due to the complex composition of wastewater. To achieve high energy efficiency, many micro-porous materials with complex functional groups have been fabricated because of their high pollutant adsorption capabilities. In this work, antibacterial beta-cyclodextrin-based nanoparticles (E-beta-CDN) were prepared via one-pot method to explore their adsorption performance to pollutants in wastewater. The resulting nanoparticles exhibited superfast adsorption kinetics to pollutants with removal efficiency of over 95% within 10 s. The nanoparticles also presented broad-spectrum adsorption to organic pollutants and heavy metal ions, and their maximum adsorption capacity was 3289.6 mg g(-1) towards methyl orange (MO) and 970.8 mg g(-1) towards Pb(II), much higher than that of many other adsorbents. Easy cyclic adsorption-desorption was another distinguishing feature of the nanoparticles, whose removal efficiency to these pollutants hardly varied after 10 cycles of regeneration. Interestingly, the resulting nanoparticles showed prominent antibacterial activity of 99.99% bacterial inhibitive rate against both gram-negative bacteria Escherichia coli (E. coli) and gram-positive bacteria Staphylococcus aureus (S. aureus). These results suggest that the resulting nanoparticles have great potential in the purification of the wastewater. (C) 2020 Elsevier Inc. All rights reserved.