Hypothesis: Certain biobased polymers or natural compounds can be effectively used in superhydrophobic coating formulations to reduce environmental impact of fluorinated compounds and related bioaccumulation and toxicity problems. Many environmental concerns have thus far been raised in relation to toxicity of solvents and C8 fluorine chemicals. Elimination of these important elements from nonwettable coating formulations can jeopardize non-wetting performance significantly. However, intelligent and innovative approaches that introduce ecofriendly resins and compounds in superhydrophobic coating formulations without significantly altering self-cleaning superhydrophobicity are possible and being reported. Experiments: Superhydrophobic coatings based on a biomass-derived bioresin polyfurfuryl alcohol (PFA) were prepared. The coatings were made by blending PFA resin with a C6 perfluorinated acrylic copolymer PFAC in solution and subsequent spray coating. Silica nanoparticles were also added in order to repel some common oils. Coating morphology, chemical and thermal properties, biocompatibility and bacterial adhesion properties were studied in detail. Findings: Coatings having 50 wt% bioresin revealed equal water-repellency performance comapred to 100% PFAC-based coatings. Healthy cell growth was maintained on the coatings with no cell toxicity using human cell line, HeLa cells. Superhydrophobic coatings demonstrated very low bacterial adhesion to E. coli, S. aureus and Ps. aeruginosa indicating promising biofouling resistance. The coatings did not require any post thermal annealing. This would cause significant energy savings for large-scale adaptation. (C) 2020 Elsevier Inc. All rights reserved.