Metal-organic frameworks based on beta-cyclodextrin and potassium cations (K-beta CD-MOF) were synthesized and characterized. Influence of nature and amount of anti-solvent, as well as molar ratio of the components and temperature on the K-beta CD-MOF synthesis was revealed. The loading of non-steroidal anti-inflammatory drugs (NSAIDs) in K-beta CD-MOF was performed by co-crystallization and impregnation methods. It was shown that chemical nature of NSAIDs strongly influences the drug loading. The maximum payload (up to 7 wt%) was reached for ibuprofen as less bulky and more lipophilic compound. The obtained composites were characterized by different experimental techniques. Ibuprofen entrapped in K-beta CD-MOF displayed improved aqueous solubility. Solubility rise is caused by formation of the inclusion complexes and clusters stabilized by beta-CD.