Anisotropic nanocatalysts have attracted considerable attention in comparison to bulk/nanocatalysts for their enhanced activity and reactivity. The demand toward anisotropic palladium (Pd) nanostructures has increased rapidly in the field of catalysis. Pd is a well-known active catalyst for several carbon- carbon (C-C) cross-coupling reactions; among them, the Suzuki- Miyaura cross-coupling reaction is one of the most versatile and dominant methods for constructing the extraordinarily useful unsymmetrical biaryls and also for hydrogenation of organic contaminants like p-nitrophenol (p-NP). This paper provides a brief explanation about the controlled synthesis, characterization, and catalytic activity of well-defined palladium nanocubes (Pd NCs) prepared by a seed-mediated method. The synthesized monodispersed Pd NCs were characterized by spectroscopic and microscopic tools such as UV-visible, XRD, FESEM, HRTEM, and EDS analyses. Pd NCs proved as an efficient catalyst for Suzuki-Miyaura cross-coupling reactions and p-NP reduction. The catalyst shows enhanced activity, greater stability, and higher selectivity with remarkable recyclability up to 92% for five consecutive cycles. The catalytic performance of the synthesized Pd NCs was also studied in the reduction of the organic contaminant p-NP, which showed an excellent performance screening of 99% conversion in 6 min.