PVGA, silver nitrate (AgNO3) and alginate (Alg) were cross-linked by using gamma-ray radiation to obtain Alg/PVGA/AgNPs as a potential biomaterial. The hydrogel composition was characterized by several analytics methods, and the morphology was evaluated by scanning electron microscopy. The swelling behavior was tested in different mediums. The stability of AgNPs was followed by UV-Vis at 400 nm for 1 month. The hydrogel soil biodegradation was analyzed by visual observation, weight loss, Fourier transform infrared spectroscopy and thermogravimetric analysis for 120 days. A simple biodegradation mechanism has been proposed based on results. Additionally, cytotoxicity assays were carried out using NCTC 929 cells to observe cell viability.