Dried Lycium ruthenicum Murray (LM) fruits were ground by three different methods. The results showed that LM powders produced by superfine-grinding had smaller particle size (1.78-200.00 mu m) as compared to shear-breaking and ball-milling. As a consequence, its bulk density, angle of repose and angle of slide were increased to 0.71 g/mL, 52.99 degrees and 60.38 degrees, respectively. Moreover, the superfine-ground LM powders displayed good dispersibility and infusion properties, showing improved water holding capacity and water solubility index than other powders during infusion. Consequently, the phytochemicals present in the superfine-ground LM powders could be released more easily, leading to the powders with higher anthocyanin and polysaccharide contents (24.50 and 160.54 mg/g) and antioxidant activities (DPPH, ABTS and FRAP: 34.53, 42.19 and 40.25 mM TE/g, respectively) than other powders. The results suggested that superfine-grinding could be a promising method for producing LM powders with higher contents of bioactive compounds and bioactivity. (C) 2020 Published by Elsevier B.V.