화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.89, 288-300, September, 2020
DOI10.1016/j.jiec.2020.05.025  Export Citation
Synthesis of highly stable and dispersed silver nanoparticles/poly (vinyl alcohol-co-ethylene glycol)/poly(3-aminophenyl boronic acid) nanocomposite: Characterization and antibacterial, hemolytic and cytotoxicity studies
Titilope John Jayeoye1, 2, Ozioma Forstinus Nwabor3, and Thitima Rujiralai1, 2, †
  • 1Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
  • 2Analytical Chemistry and Environment Research Unit, Division of Chemistry, Department of Science, Faculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand
  • 3Department of Microbiology, University of Nigeria, Nsukka, Nigeria
E-mail:
A highly stable and dispersed aqueous nanocomposite of silver nanoparticles/poly(vinyl alcohol-coethylene glycol)/poly(3-aminophenyl boronic acid) (Ag/(PVA-PEG)/PABA) was synthesized. PVA and PEG was blended at the optimum volume ratio of 16:4 to obtain poly(vinyl alcohol-co-ethylene glycol) (PVA-PEG) blend. 3-Aminophenyl boronic acid served as the reductant of silver nitrate and was in situ oxidatively polymerized to obtain poly(3-aminophenyl boronic acid) (PABA). Subsequently, (PVA-PEG) blend served as matrix for PABA polymerization. The polymer blend helped to improve PABA solubility by providing platform for PABA anchoring, through covalent bonding with the free hydroxyl groups of the blend. Additionally, PABA is a highly conducting polymer, hence the synthesized nanocomposite demonstrated improved conductivity. The maximum absorption peak of Ag/(PVA-PEG)/PABA was at 422 nm, with particle sizes between 10 and 15 nm and zeta potential value of 25.8 mV. FESEM showed spherical AgNPs sprinkled on the surface of the nanocomposite while 40% Ag was presented in EDX result. The Ag/(PVA-PEG)/PABA exhibited good antibacterial potency against Bacillus cereus and Escherichia coli where the ruptured bacterial cell was observed on FESEM. Importantly, it showed reliable biocompatibility without imparting deleterious red blood cell hemolysis and non-cytotoxic to normal human cell line. Overall, these results emphasized the exciting biomedical potentials of Ag/(PVA-PEG)/ PABA nanocomposite.
Keywords:Silver nanoparticles;In situ polymerization;3-Aminophenyl boronic acid;Poly(vinyl alcohol);Poly(ethylene glycol);Biocompatibility
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