화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.90, 371-378, October, 2020
DOI10.1016/j.jiec.2020.07.038  Export Citation
Enhancing antibacterial activity of geminized cationic amphiphilic polymer via structure control and self-assembly regulation
Ting Chen1, 2, †, Lianyu Zhao1, 2, Ziyuan Wang1, 2, Jishi Zhao1, 2, Yan Li1, 2, Hangyu Long1, and Ming Yang3
  • 1School of Materials Science and Hydrogen Energy, Foshan University, Foshan, Guangdong 528000, China
  • 2Foshan Institute of Environmental and Energy Technology, Foshan, Guangdong 528000, China
  • 3R&D Center of Hydrogen Energy Standardization, Yunfu, Guangdong 527300, China
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A novel geminized amphiphilic polymer containing double cationic head groups and hydrophobic tails in each structural unit (denoted as PAGBn), has been prepared in our study. The self-assembly behavior on the solid/liquid interface was investigated by quartz crystal microbalance with dissipation (QCM-D), steady-state fluorescence, dynamic light scattering (DLS) and transmission electron microscope (TEM). A two-regime buildup can be observed, where the first regime is attributed to the rapid adsorption of polymers, while a rearrangements of pre-adsorbed molecules and their aggregation on the surface dominate the second regime, exhibiting a formation of aggregates in large sizes due to the effect of the charge density and hydrophobes on the self-assembly process. It exhibits a drastically enhanced killing efficiency of 99.9% against both of Staphylococcus aureus and Escherichia coli bacteria for PAGBn compared with other traditional single-chained polymers, through the reinforced synergistic effect of electrostatic and hydrophobic interactions, and the formation of large-sized polymer aggregates, encompassing and killing the bacteria more efficiency. Our findings reveal the antibacterial mechanism and the correlation between antibacterial activity and aggregates structure, providing a basis for the development of super-antibacterial materials in the infection resistant applications.
Keywords:Geminized amphiphilic polymers;Molecular self-assembly;Super-antibacterial activity
  1. Ren W, Cheng WR, Wang G, Liu Y, J. Polym. Sci. A: Polym. Chem., 55(4), 632 (2017)
  2. Santos MRE, Fonseca AC, Mendona PV, Branco R, Serra AC, Morais PV, Coelho JFJ, Materials, 9(7), 33 (2016)
  3. Chen A, Peng H, Blakey I, Whittaker AK, Polym. Rev., 57(2), 276 (2017)
  4. Kim DW, Moon JM, Park SY, Choi JS, Cho WK, J. Ind. Eng. Chem., 68, 42 (2018)
  5. Timofeeva L, Kleshcheva N, Appl. Microbiol. Biotechnol., 89(3), 475 (2011)
  6. Kaur R, Liu S, Prog. Surf. Sci., 91(3), 136 (2016)
  7. Duan CX, Yu Y, Yang PF, Zhang XL, Li FE, Li LB, Xi HX, Ind. Eng. Chem. Res., 59(2), 774 (2020)
  8. Jadhav M, Kalhapure RS, Rambharose S, Mocktar C, Govender T, J. Ind. Eng. Chem., 47, 405 (2017)
  9. Hu X, LinX, Zhao H, Chen Z, Yang J, Li F, Liu C, Tian F, Materials, 9, 376 (2016)
  10. Roy D, Knapp JS, Guthrie JT, Perrier S, Biomacromolecules, 9(1), 91 (2008)
  11. Kugler R, Bouloussa O, Rondelez F, Microbiology, 151, 1341 (2005)
  12. Lee SB, Koepsel RR, Morley SW, Matyjaszewski K, Sun YJ, Russell AJ, Biomacromolecules, 5(3), 877 (2004)
  13. Pan Y, Xia Q, Xiao H, Polymers, 11(8), 1283 (2019)
  14. Oblak E, Piecuch A, Rewak-Soroczynska J, Paluch E, Appl. Microbiol. Biotechnol., 103(2), 625 (2019)
  15. Lv X, Liu C, Song S, Qiao Y, Hu Y, Li P, Li Z, Sun S, RSC Adv., 8(6), 2941 (2018)
  16. Sharma R, Kamal A, Abdinejad M, Mahajan RK, Kraatz HB, Adv. Colloid Interface Sci., 248, 35 (2017)
  17. Murata H, Koepsel RR, Matyjaszewski K, Russell AJ, Biomaterials, 28(32), 4870 (2007)
  18. Zhu XY, Janczewski D, Guo SF, Lee SSC, Velandia FJP, Teo SLM, He T, Puniredd SR, Vancso GJ, ACS Appl. Mater. Interfaces, 7(1), 852 (2015)
  19. Wang H, Shi XF, Yu DF, Zhang J, Yang G, Cui YX, Sun KJ, Wang JB, Yan HK, Langmuir, 31(50), 13469 (2015)
  20. Zhou C, Wang H, Bai H, Zhang P, Liu L, Wang S, Wang Y, ACS Appl. Mater. Interfaces, 9(37), 31657 (2017)
  21. Chen T, Yang H, Wu X, Yu DF, Ma AQ, He X, Sun KJ, Wang JB, Langmuir, 35(8), 3031 (2019)
  22. Yu DF, Yang H, Wang H, Cui YX, Yang G, Zhang J, Wang JB, Langmuir, 30(48), 14512 (2014)
  23. Liu GM, Yan LF, Chen X, Zhang GZ, Polymer, 47(9), 3157 (2006)
  24. Ghimici L, Nichifor M, J. Colloid Interface Sci., 302(2), 589 (2006)
  25. Li RQ, Wei LB, Hu CC, Xu CF, Wang JB, J. Phys. Chem. B, 114(39), 12448 (2010)
  26. Gaudreault R, Di Cesare N, Weitz D, van de Ven TGM, Colloids Surf. A: Physicochem. Eng. Asp., 340(1-3), 56 (2009)
  27. Zhou C, Wang F, Chen H, Li M, Qiao F, Liu Z, Hou Y, Wu C, Fan Y, Liu L, Wang S, Wang Y, ACS Appl. Mater. Interfaces, 8(6), 4242 (2016)
  28. Yang H, Duan HB, Wu X, Wang M, Chen T, Liu FH, Huang SZ, Zhang W, Chen G, Yu DF, Wang JB, Langmuir, 32(44), 11485 (2016)
  29. Zhang MH, Yang H, Wang SJ, Zhang W, Hou QF, Guo DH, Liu FH, Chen T, Wu X, Wang JB, J. Phys. Chem. B, 122(25), 6648 (2018)
  30. Chen T, Liu FH, Huang SZ, Zhan W, Wang H, Hou QF, Guo DH, Ma AG, Sun KJ, Yang H, Wang JB, Energy Fuels, 30(11), 9250 (2016)
  31. Wang H, Zhang P, Shi X, Yu D, Wang J, Yan H, Ji G, Soft Matter, 10(35), 6749 (2014)
  32. Qiao Yang C, Coady DJ, Ong ZY, Hedrick JL, Yang YY, Biomaterials, 33(4), 1146 (2012)
  33. Zhou C, Wang F, Chen H, Li M, Qiao F, Liu Z, Hou Y, Wu C, Fan Y, Liu L, Wang S, Wang Y, ACS Appl. Mater. Interfaces, 8, 4242 (2016)
  34. Kannan R, Prabakaran P, Basu R, Pindi C, Senapati S, Muthuvijayan V, Prasad E, ACS Appl. Bio Mater., 2(8), 3212 (2019)