High Performance Detection of Alzheimer’s Disease Biomarkers Based on Localized Surface Plasmon Resonance

Tan Nhiem Ly; Sangkwon Park

Journal of Industrial and Engineering Chemistry, Vol.91, 182-190, November, 2020

DOI10.1016/j.jiec.2020.07.051 Export Citation

High Performance Detection of Alzheimer’s Disease Biomarkers Based on Localized Surface Plasmon Resonance

Tan Nhiem Ly, and Sangkwon Park^†

Department of Chemical and Biochemical Engineering, Dongguk University, Pildong-ro 1-gil 30, Jung-gu, Seoul, 04620, South Korea

E-mail:

In this study, we fabricated sensors to detect Alzheimer’s disease (AD) biomarkers ? amyloid beta (1-42) (Aβ1-42) based on localized surface plasmon resonance (LSPR). The sensors were consisted of ligand-exchanged gold nanoparticles (Au NPs) deposited on polyethylene terephthalate substrate using Langmuir-Blodgett (LB) technique. Monoclonal antibodies (anti-Aβ1-42) were then immobilized as a conjugate form with biotin onto the LB films of ligand-exchanged Au NPs by the aid of streptavidin. The attachment of the biomarkers to the antibodies immobilized on the LB films was detected by measuring absorbance change of plasmonic response peak. The sensor structure was optimized by comparing the results for the Au NPs LB films with different size and film thickness. The optimized sensor was used to detect biomarker at different concentrations in the buffer solution and a diluted cerebrospinal fluid (CSF) solution. As results, the sensor was able to detect even a trace amount of Aβ1-42 as small as 1?pg/ml from the CSF. This prototype sensor has a great potential because it shows several advantages of facile and inexpensive fabrication, and early detection of the AD.

Keywords:Alzheimer’s Disease;Biomarker;High Performance Detection;Localized Surface Plasmon Resonance

[References]

Suh YH, Checler F, Pharmacol. Rev., 54, 469 (2002)
Prince M, Comas-Herrera A, Knapp M, Guerchet M, Karagiannidou M, World Alzheimer report (2016).
Mehta PD, Pirttila T, Mehta SP, Sersen EA, Aisen PS, Wisniewski HM, Arch. Neurol., 57, 100 (2000)
Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Dore V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K, Nature, 554(7691), 249 (2018)
Brickman AM, Tosto G, Gutierrez J, Andrews H, Gu Y, Narkhede A, Rizvi B, et al., Neurology, 91, e1402 (2018)
Smith AD, Jobst KA, Szatmari M, Jaskowski A, King E, Smith A, Molyneux A, Esiri ME, McDonald B, Wald N, The Lancet, 340, 1179 (1992)
Bozzali M, Falini A, Franceschi M, Cercignani M, Zuffi M, Scotti G, Comi, Filippi M, J. Neurol. Neurosurg. Psychiatry, 72, 742 (2002)
Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW, Cereb. Cortex, 1, 103 (1991)
Tapiola T, Alafuzoff I, Herukka SK, Parkkinen L, Hartikainen P, Soininen H, Pirttila T, Arch. Neurol., 66, 382 (2009)
Kaushik A, Jayant RD, Tiwari S, Vashist A, Nair M, Biosens. Bioelectron., 80, 273 (2016)
Lien TTN, Takamura Y, Tamiya E, Vestergaard MC, Anal. Chim. Acta, 892, 69 (2015)
Ammar M, Smadja C, Phuong LGT, Azzouz M, Vigneron J, Etcheberry A, Taverna M, Dufour-Gergam E, Biosens. Bioelectron., 40, 329 (2013)
Neely A, Perry C, Varisli B, Singh AK, Arbneshi T, Senapati D, Kalluri JR, Ray PC, ACS Nano, 3, 2834 (2009)
Zhou W, Gao X, Liu DB, Chen XY, Chem. Rev., 115(19), 10575 (2015)
Nam JM, Thaxton CS, Mirkin CA, Science, 301, 1884 (2003)
Haes AJ, Haynes CL, McFarland AD, Schatz GC, Duyne RPV, Zou S, MRS Bull., 30, 368 (2005)
Kelly KL, Coronado E, Zhao LL, Schatz GC, J. Phys. Chem. B, 107(3), 668 (2003)
Miller MM, Lazarides AA, J. Phys. Chem. B, 109(46), 21556 (2005)
Oh SY, Heo NS, Shukla S, Cho HJ, Vilian ATE, Kim J, Lee SY, Han YK, Yoo SM, Huh YS, Sci. Rep., 7, 10130 (2017)
Rodriguez-Lorenzo L, de la Rica R, Alvarez-Puebla RA, Liz-Marzan LM, Stevens MM, Nat. Mater, 11, 604 (2012)
Ly TN, Park SK, J. Ind. Eng. Chem., 67, 417 (2018)
Ly TN, Park S, Park SJ, Sens. Actuators B-Chem., 237, 452 (2016)
Su XD, Wu YJ, Robelek R, Knoll W, Langmuir, 21(1), 348 (2005)
Swann MJ, Peel LL, Carrington S, Freeman NJ, Anal. Biochem., 329, 190 (2004)
Lapin NA, Chabal YJ, J. Phys. Chem. B, 113(25), 8776 (2009)
Jung LS, Campbell CT, Chinowsky TM, Mar MN, Yee SS, Langmuir, 14(19), 5636 (1998)
Nath N, Chilkoti A, Anal. Chem., 76, 5370 (2004)
Kedem O, Tesler AB, Vaskevich A, Rubinstein I, ACS Nano, 5, 748 (2011)
Jia K, Bijeon JL, Adam PM, Ionescu RE, Anal. Chem., 84, 8020 (2012)
Ekgasit S, Thammacharoen C, Yu F, Knoll W, Appl. Spectrosc., 59, 661 (2005)
Haes AJ, Van Duyne RP, J. Am. Chem. Soc., 124(35), 10596 (2002)
Di Terlizzi R, Platt S, Vet. J., 172, 422 (2006)
Costa M, Ortiz AM, Jorquera JI, J. Alzheimers Dis., 92, 159 (2012)
Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ, J. Biol. Chem., 271, 32916 (1996)
Bolduc OR, Clouthier CM, Pelletier JN, Masson JF, Anal. Chem., 81, 6779 (2009)
Li SS, Lin CW, Wei KC, Huang CY, Hsu PH, Liu HL, Lu YJ, Lin SC, Yang HW, Ma CCM, Sci. Rep., 6, 25155 (2016)
Wu CC, Ku BC, Ko CH, Chiu CC, Wang GJ, Yang YH, Wu SJ, Electrochim. Acta, 134, 249 (2014)
Oh J, Yoo G, Chang YW, Kim HJ, Jose J, Kim E, Pyun JC, Yoo KH, Biosens. Bioelectron., 50, 345 (2013)
Carneiro P, Loureiro J, Delerue-Matos C, Morais S, do Carmo Pereira M, Sens. Actuators B-Chem., 239, 157 (2017)
Zhao Z, Zhu L, Bu X, Ma H, Yang S, Yang Y, Hu Z, Chem. Commun., 51, 718 (2014)

[1] Suh YH, Checler F, Pharmacol. Rev., 54, 469 (2002)

[2] Prince M, Comas-Herrera A, Knapp M, Guerchet M, Karagiannidou M, World Alzheimer report (2016).

[3] Mehta PD, Pirttila T, Mehta SP, Sersen EA, Aisen PS, Wisniewski HM, Arch. Neurol., 57, 100 (2000)

[4] Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Dore V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K, Nature, 554(7691), 249 (2018)

[5] Brickman AM, Tosto G, Gutierrez J, Andrews H, Gu Y, Narkhede A, Rizvi B, et al., Neurology, 91, e1402 (2018)

[6] Smith AD, Jobst KA, Szatmari M, Jaskowski A, King E, Smith A, Molyneux A, Esiri ME, McDonald B, Wald N, The Lancet, 340, 1179 (1992)

[7] Bozzali M, Falini A, Franceschi M, Cercignani M, Zuffi M, Scotti G, Comi, Filippi M, J. Neurol. Neurosurg. Psychiatry, 72, 742 (2002)

[8] Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW, Cereb. Cortex, 1, 103 (1991)

[9] Tapiola T, Alafuzoff I, Herukka SK, Parkkinen L, Hartikainen P, Soininen H, Pirttila T, Arch. Neurol., 66, 382 (2009)

[10] Kaushik A, Jayant RD, Tiwari S, Vashist A, Nair M, Biosens. Bioelectron., 80, 273 (2016)

[11] Lien TTN, Takamura Y, Tamiya E, Vestergaard MC, Anal. Chim. Acta, 892, 69 (2015)

[12] Ammar M, Smadja C, Phuong LGT, Azzouz M, Vigneron J, Etcheberry A, Taverna M, Dufour-Gergam E, Biosens. Bioelectron., 40, 329 (2013)

[13] Neely A, Perry C, Varisli B, Singh AK, Arbneshi T, Senapati D, Kalluri JR, Ray PC, ACS Nano, 3, 2834 (2009)

[14] Zhou W, Gao X, Liu DB, Chen XY, Chem. Rev., 115(19), 10575 (2015)

[15] Nam JM, Thaxton CS, Mirkin CA, Science, 301, 1884 (2003)

[16] Haes AJ, Haynes CL, McFarland AD, Schatz GC, Duyne RPV, Zou S, MRS Bull., 30, 368 (2005)

[17] Kelly KL, Coronado E, Zhao LL, Schatz GC, J. Phys. Chem. B, 107(3), 668 (2003)

[18] Miller MM, Lazarides AA, J. Phys. Chem. B, 109(46), 21556 (2005)

[19] Oh SY, Heo NS, Shukla S, Cho HJ, Vilian ATE, Kim J, Lee SY, Han YK, Yoo SM, Huh YS, Sci. Rep., 7, 10130 (2017)

[20] Rodriguez-Lorenzo L, de la Rica R, Alvarez-Puebla RA, Liz-Marzan LM, Stevens MM, Nat. Mater, 11, 604 (2012)

[21] Ly TN, Park SK, J. Ind. Eng. Chem., 67, 417 (2018)

[22] Ly TN, Park S, Park SJ, Sens. Actuators B-Chem., 237, 452 (2016)

[23] Su XD, Wu YJ, Robelek R, Knoll W, Langmuir, 21(1), 348 (2005)

[24] Swann MJ, Peel LL, Carrington S, Freeman NJ, Anal. Biochem., 329, 190 (2004)

[25] Lapin NA, Chabal YJ, J. Phys. Chem. B, 113(25), 8776 (2009)

[26] Jung LS, Campbell CT, Chinowsky TM, Mar MN, Yee SS, Langmuir, 14(19), 5636 (1998)

[27] Nath N, Chilkoti A, Anal. Chem., 76, 5370 (2004)

[28] Kedem O, Tesler AB, Vaskevich A, Rubinstein I, ACS Nano, 5, 748 (2011)

[29] Jia K, Bijeon JL, Adam PM, Ionescu RE, Anal. Chem., 84, 8020 (2012)

[30] Ekgasit S, Thammacharoen C, Yu F, Knoll W, Appl. Spectrosc., 59, 661 (2005)

[31] Haes AJ, Van Duyne RP, J. Am. Chem. Soc., 124(35), 10596 (2002)

[32] Di Terlizzi R, Platt S, Vet. J., 172, 422 (2006)

[33] Costa M, Ortiz AM, Jorquera JI, J. Alzheimers Dis., 92, 159 (2012)

[34] Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ, J. Biol. Chem., 271, 32916 (1996)

[35] Bolduc OR, Clouthier CM, Pelletier JN, Masson JF, Anal. Chem., 81, 6779 (2009)

[36] Li SS, Lin CW, Wei KC, Huang CY, Hsu PH, Liu HL, Lu YJ, Lin SC, Yang HW, Ma CCM, Sci. Rep., 6, 25155 (2016)

[37] Wu CC, Ku BC, Ko CH, Chiu CC, Wang GJ, Yang YH, Wu SJ, Electrochim. Acta, 134, 249 (2014)

[38] Oh J, Yoo G, Chang YW, Kim HJ, Jose J, Kim E, Pyun JC, Yoo KH, Biosens. Bioelectron., 50, 345 (2013)

[39] Carneiro P, Loureiro J, Delerue-Matos C, Morais S, do Carmo Pereira M, Sens. Actuators B-Chem., 239, 157 (2017)

[40] Zhao Z, Zhu L, Bu X, Ma H, Yang S, Yang Y, Hu Z, Chem. Commun., 51, 718 (2014)