화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.94, 62-77, February, 2021
DOI10.1016/j.jiec.2020.11.015  Export Citation
Immunotherapeutic strategies for the treatment of ovarian cancer: current status and future direction
Ramesh Duwa, Jee-Heon Jeong1, †, and Simmyung Yook†
  • College of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea
  • 1College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea
E-mail:,
Ovarian cancer is the most significant cause of gynecological cancer mortality, with the majority of women with advanced disease. Although surgery and chemotherapy can enhance survival rates, the 5-year survival rates remain low at 45%. So, alternative treatment options need to be implemented to improve therapeutic outcomes. In the ovarian cancer tumor, the presence of T cells helps to improve the progression-free and overall survival, whereas a poor prognosis corresponds to the presence of regulatory T cells and expression of T cells inhibitory molecules. Analyzing the important role of these immune systems in cancer management, immunotherapy may create a sustained response to recurring ovarian cancer cells in the immune system. In addition, by boosting anti-tumor immune response, women’s prognosis with this lethal disease can be significantly influenced. Different immunotherapeutic strategies and nanoparticle-based strategies were used as potential treatment options to challenge tumor progression. This review discusses cytokine therapy, peptide vaccine, monoclonal antibody, dendritic cell-based vaccine, adoptive T cells transfer, and immune checkpoint inhibitors as well as different nanoparticles such as poly (lactic-co-glycolic) acid nanoparticles, polyethyleneimine-based nanoparticles, and liposomes that offer a new paradigm in the treatment of ovarian cancer.
Keywords:Immune system;Immunotherapy;Nanoparticle;Ovarian cancer;Poly (lactic-co-glycolic) acid nanoparticles;Liposomes;T cells
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