Ultrasound-based fractional precipitation for the purification of (+)-dihydromyricetin

Se-Rin Oh; Jin-Hyun Kim

Korean Journal of Chemical Engineering, Vol.38, No.3, 480-484, March, 2021

DOI10.1007/s11814-020-0734-8 Export Citation

Ultrasound-based fractional precipitation for the purification of (+)-dihydromyricetin

Se-Rin Oh, and Jin-Hyun Kim^†

Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea

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The purification efficiency of (+)-dihydromyricetin, a bioactive plant flavonoid, was remarkably improved through ultrasound-based fractional precipitation. The precipitation time (up to 30 min) taken to obtain (+)-dihydromyricetin with high purity (87.01-91.66%) and yield (90.63-92.00%) through the ultrasonic fractional precipitation (ultrasonic power: 80-250W) was shortened by 40-fold as compared to the conventional method (up to 1200 min). In addition, the precipitation rate constant was increased by 12- to 18-fold, but the activation energy was decreased to between -5,787 J/mol and -6,526 J/mol, and thereby the precipitation rate was improved. Furthermore, the size of the precipitate was reduced by 5.1- to 5.5-fold, while the diffusion coefficient was increased by 6.4- to 6.9-fold.

Keywords:(+)-Dihydromyricetin;Fractional Precipitation;Ultrasound;Kinetics;Diffusion Coefficient

[References]

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Li F, Raza A, Wang YW, Xu XQ, Chen GH, Phcog. Mag., 13, 446 (2017)
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Zhang Y, CN Patent, 1,393,443 (2003).
Lee KH, Kim JH, Biotechnol. Bioprocess Eng., 13, 274 (2008)
Kim MK, Kim JH, Korean J. Microbiol. Biotechnol., 42, 25 (2014)
Seo HW, Kim JH, Process Biochem., 87, 238 (2019)
Davies LA, Dargue A, Dean JR, Deary ME, Ultrason. Sonochem., 23, 424 (2015)
Kang HJ, Kim JH, Process Biochem., 99, 316 (2020)
Jordens J, Coker ND, Gielen B, Gerven TV, Braeken L, Ultrason. Sonochem., 26, 64 (2015)
Ha GS, Kim JH, Korean J. Chem. Eng., 34(9), 2451 (2017)
Park JN, Kim JH, Process Biochem., 53, 224 (2017)
Wohgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64(19), 4155 (2009)
Guo Z, Zhang M, Li H, Wang J, Kougoulos E, J. Cryst. Growth, 273(3-4), 555 (2005)
Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, Cho JM, Yun G, Lee J, Asian J. Pharm. Sci., 9, 304 (2014)
Kim MJ, Kim JH, Korean Chem. Eng. Res., 54(2), 278 (2016)
Ma D, Marshall JS, Wu J, J. Acoust. Soc. Am., 144, 3496 (2018)
Guo Z, Jones AG, Li N, Chem. Eng. Sci., 61, 1617 (2008)
Wolloch L, Kost J, J. Control. Release, 148, 204 (2010)

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