This paper presents a study of gas-solid flow in a novel cyclone separator with inner cylinder, compared with that in a conventional cyclone. The Reynolds stress model (RSM) is used to simulate fluid flow, and the discrete phase model (DPM) is selected to describe the motion behavior of particles. The experimental data measured by particle image velocimetry (PIV) is used to verify the reliability of the numerical model. The results show that in the novel cyclone, the cleaned gas can be quickly discharged from the vortex finder, the movement distance and residence time of fine particles are prolonged, the short-circuit flow and vertical vortex under the vortex finder are eliminated, the mutual interference between upflow and downflow in the cylinder is eliminated, and the region of quasi-free vortex in the cone is enlarged. Compared with the conventional cyclone, the novel cyclone has higher collection efficiency and lower pressure drop. (C) 2020 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.