The balance of protein, carbohydrate, and fat affect the composition and functions of the gut microbiota. The complexities involved thereof require insights into the roles and impacts of individual dietary components due to the difficulty of defining such in a group of others. Peptides and proteins from several animal and plant sources have been widely explored in relation to the gut microbiome modulation, but the effects of soy peptides and other soy derivatives on the gut microbiota are largely unexplored. This piece considered an overview of the production and interventions of soy bioactive peptides on gut, as they affect the composition and functions of the gut microorganisms. A mini review on the production of soy protein hydrolysates/peptides and highlights of the most recent knowledge regarding their physiological effects on host's gut microbiota cum health were investigated. Overall deductions and research gaps were critically evaluated for futuristic interventions and relevance.