In this paper, the solubility of 4-nitroirnidazole in twelve pure solvents (toluene. benzene, 1,4-dioxane, acetonitrile, ethyl acetate, acetone. GBL, ethanol, methanol, n-butanol. DMF and NMP) were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 kPa, which are 0.00018-0.00070, 0.00021-0.00073, 0.00034-0.00092, 0.00038-0.00142, 0.00047-0.00120,0.00126-0.00303, 0.00225-0.00517, 0.00310-0.00724,0.00467-0.00982, 0.00453-0.01940, 0.01947-0.04652, and 0.04670-0.07452, respectively. At constant temperature, the mole fraction solubility of 4-nitroimidazole were increased as the following order: toluene < benzene < 1,4-dioxane < (ethyl acetate or acetonitrile) < acetone < GBL < ethanol < (methanol or nbutanol) < DMF < NMP, and the solubility of 4-nitroimidazole in (ethyl acetate, acetonitrile) and (methanol, n-butanol) had an intersection point at 297.55 K and 281.85 K, respectively. The solubility of 4-nitroimidazole could be increased with increasing temperature in twelve pure solvents. The ideal model, modified Apelblat equation, polynomial empirical equation, and lambda h equation were used to correlate the experimental values. The experimental solubility values were employed to calculate the standard dissolution enthalpy, standard dissolution entropy and Gibbs energy. The dissolution of 4-nitroirnidazole could be an endothermic process in twelve pure solvents. The determination and fitting solubility of 4-nitroimidazole have important guiding significance for the purification and crystallization of its preparation process. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. Co., Ltd. All rights reserved.