A Pt/TiO2 catalyst fabricated via a sacrificial carbon layer strategy has been studied for the selective catalytic reduction (SCR) of NOx with H-2. Modified Pt/TiO2 exhibited superior low-temperature activity for the reduction of NOx in a wide temperature window (100-250 degrees C). Through the sacrificial carbon layer strategy, the strong metal-support interaction (SMSI) was induced over the modified Pt/TiO2. SMSI effect gives rise to electron transfer from TiO2 to Pt and forms more Pt-0 species, which are the favorable active sites for the H-2-SCR of NOx. Furthermore, in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) studies demonstrated that the SMSI effect not only promotes the adsorption and activation of NOx but also improves the reactivity of the adsorbed NOx species and the formation of more new, active NH3 species. As a consequence, the H-2-SCR performance of the modified Pt/TiO2 is significantly enhanced. Our study demonstrated the key role of SMSI engineering and paves a new way for fabricating high-performance H-2-SCR catalysts for the practical removal of NOx.