The reaction of In3+ ions with 2,S-di(2H-tetrazol-S-yl) terephthalic acid (H(4)dtztp) affords a 3D indium-organic framework, [In(dtztp)(0.5)(OH)(H2O)]center dot H2O (1) with a (3,6)-connected net. 1 shows good thermal (300 degrees C) and chemical stabilities (various organic solvents and acidic/basic solutions) and excellent water tolerance (7 days at room temperature or in boiling water). The acetylene (C2H2) sorption behavior of 1 indicates significant separation selectivity over CH4, as confirmed by breakthrough experiments on the realistic gas mixtures. Meanwhile, the MOF with the Lewis and Bronsted acidic bifunctional catalytic sites catalyzes the CO2 conversion with different epoxides with high yields. The fluorescent properties reveal the efficient probing performance of 1 for nitrofurantoin (NFT) and metronidazole (MDZ) in water with a low detection limit (ppm).