We report on the synthesis and characterization of the first polyoxo-noble-metalate-containing metal-organic framework (MOF) material, wherein the preformed MIL-101 has been impregnated with the discrete, cuboid-shaped polyoxopalladate [Pd13Se8O32](6-) (Pd13Se8), leading to the composite Pd13Se8@MIL-101. This material was characterized by FTIR, TGA, elemental analysis, powder-XRD, N-2 sorption (BET), SEM-EDX, and XPS. Furthermore, the Pd13Se8@MIL-101 composite was shown to be an effective, stable, and recyclable heterogeneous precatalyst for the Suzuki-Miyaura cross-coupling reaction at room temperature utilizing environmentally benign solvents, such as water and methanol.