Pinus densiflora와 Pinus koraiensis로부터 분리된 생리활성 물질들 및 응용

김남희; 윤순권; 엄병헌; 김정원; Nam Hee Kim; Sunkwon Yoon; Byung-Hun Um; Jung Won Kim

Applied Chemistry for Engineering, Vol.32, No.2, 132-138, April, 2021

DOI10.14478/ace.2021.1024 Export Citation

Pinus densiflora와 Pinus koraiensis로부터 분리된 생리활성 물질들 및 응용

Bioactive Compounds Isolated from Pinus densiflora and koraiensis and their Applications

김남희, 윤순권¹, 엄병헌^{2, †}, 김정원 ^{3, †}

(주)대산
¹(주)천년관솔
²한국과학기술연구원 천연물연구소
³강원대학교 에너지공학부(에너지화학공학전공)

Nam Hee Kim, Sunkwon Yoon¹, Byung-Hun Um^{2, †}, and Jung Won Kim^{3, †}

DAESAN Inc., Gangneung 25440, Republic of Korea
¹Cheonnyeongwansol Inc., Pocheon 11137, Republic of Korea
²Natural Products Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25441, Republic of Korea
³Department of Chemical Engineering, Kangwon National University, Samcheok 25913, Republic of Korea

E-mail:,

초록

본 리뷰에서는 대한민국에서 자생하고 있는 소나무와 잣나무들로부터 분리.추출되는 생리활성 물질의 종류, 그리고 그 효과성에 대한 연구 현황 및 산업적 활용에 대해 조사하였다. 소나무와 잣나무에는 정유, 폴리페놀, 레진, 스틸벤유도체를 비롯한 다양한 생리활성 물질들이 함유되어 있다. 최근 국내 연구진들은 소나무와 잣나무의 추출물들로부터 항산화, 항염증, 항균, 백내장 예방, 신경보호 등의 생리활성을 규명하였다. 그 추출물들은 식품, 건강기능식품, 화장품, 생활용품 등의 다양한 산업 분야에서 활용되고 있으나, 산업적으로 높은 비중을 차지하고 있는 것은 외래종을 원료로 한 것이다. 그러므로 과학적으로 규명되고 있는 효과에 비해 생리활성을 실제 제품에 응용한 사례들이 부족하여 산업적 활용성에 대한 다양한 연구가 필요하다.

This review investigated the types of physiologically active substances isolated and extracted from Pinus densiflora and koraiensis native to Republic of Korea, and the current status of research on their effectiveness and industrial use. They contain various bioactive substances including essential oils, polyphenols, resins, and stilbene derivatives. In recent, physiological activities such as antioxidant, anti-inflammatory, antibacterial, cataract prevention, and neuroprotection from extracts of Pinus densiflora and koraiensis have been identified by domestic researchers. The extracts have been used in different industrial fields like food, health functional foods, cosmetics, and household goods, but the high proportion of them is industrially made from exotic species. Therefore, various studies on industrial applicability are needed due to the lack of cases in which the activity is applied to actual products, with respect to the effects that have been scientifically recognized.

Keywords:Pinus densiflora;Pinus koraiensis;Bioactive;Polyphenols;Stilbene derivatives

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Kim JS, Prev. Nutr. Food Sci., 23, 134 (2018)
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Park SH, Kim K, Kim M, Choi JS, Cho Y, Ahn DH, J. Life Sci., 27, 646 (2017)
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D’Andrea G, Fitoterapia, 81, 724 (2010)
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Grether-Beck S, Marini A, Jaenicke T, Krutmann J, Skin Pharmacol. Physiol., 29, 13 (2016)
Yazaki Y, Nat. Prod. Commun., 10, 513 (2015)
Icel E, Ucak T, Agcayazi B, Karakurt Y, Yilmaz H, Cimen FK, Suleyman H, Cutan. Ocul. Toxicol., 37, 396 (2018)
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[1] Kwon O, Science of Life, Life of Science, 63-70, Korean Library Association, Republic of Korea (2008).

[2] Lee SK, Lee HJ, Min HY, Park EJ, Lee KM, Ahn YH, Cho YJ, Pyee JH, Fitoterapia, 76, 258 (2005)

[3] Hwang HJ, Lee HY, Han W, Kim SY, Korean J. Plant Res., 27, 1 (2014)

[4] Khawand TE, Courtois A, Valls J, Krisa S, Phytochem. Rev., 17, 1007 (2018)

[5] Hasan MM, Cha M, Bajpai VK, Baek K, Rev. Environ. Sci. Biotechnol., 12, 209 (2013)

[6] Marmo I, Quero J, Ancin-Azpilicueta C, Trends Food Sci. Technol., 88, 558 (2019)

[7] Gernandt DS, Lopez GG, Garcia SO, Liston A, Taxon, 54, 29 (2005)

[8] Zeb U, Dong W, Zhang T, Wang R, Li ZH, J. Syst. Evol., 28, 1 (2019)

[9] Kong WS, J. Geol. Soc. Korea, 41, 73 (2006)

[10] Hwang BH, Lee HJ, Kang HY, Liu S, Cho JH, Zhao J, J. Forest Environ. Sci., 13, 134 (1997)

[11] Song HK, J. Korean Wood Sci. Technol., 29, 97 (2001)

[12] Ahn HY, Heo SJ, Kang MJ, Lee JH, Cho YS, J. Life Sci., 21, 746 (2011)

[13] Balasundram N, Sundram K, Samman S, Food Chem., 99, 191 (2006)

[14] Park G, Kim Y, J. Soc. Cosmet. Scientists Korea, 42, 203 (2016)

[15] Kim JO, Cho N, J. Korean Biol. Nurs. Sci., 44, 13 (2014)

[16] Kim J, Choung SY, Mol. Vis., 23, 638 (2017)

[17] Kim JW, Im S, Jeong H, Jung YS, Lee I, Kim KJ, J. Microbiol. Biotechnol., 28, 679 (2018)

[18] Kim JS, Prev. Nutr. Food Sci., 23, 134 (2018)

[19] Venkatesan T, Choi YW, Kim YK, Biomed Res. Int., 2019, 1 (2019)

[20] Park SH, Kim K, Kim M, Choi JS, Cho Y, Ahn DH, J. Life Sci., 27, 646 (2017)

[21] Lee DG, Lee SJ, Rodriguez JP, Kim IH, Chang T, Lee S, J. Appl. Biol. Chem., 60, 213 (2017)

[22] Rohdewald P, Int. J. Clin. Pharmacol. Ther., 40, 158 (2002)

[23] D’Andrea G, Fitoterapia, 81, 724 (2010)

[24] Sahebkar A, J. Cardiovasc. Pharmacol. Ther., 19, 244 (2014)

[25] Grether-Beck S, Marini A, Jaenicke T, Krutmann J, Skin Pharmacol. Physiol., 29, 13 (2016)

[26] Yazaki Y, Nat. Prod. Commun., 10, 513 (2015)

[27] Icel E, Ucak T, Agcayazi B, Karakurt Y, Yilmaz H, Cimen FK, Suleyman H, Cutan. Ocul. Toxicol., 37, 396 (2018)

[28] Jeong MJ, Jeong SJ, Lee SH, Kim YS, Choi BD, Appl. Microsc., 43, 133 (2013)

[29] Dridi W, Bordenave N, Curr. Pharm. Des., 26, 1866 (2020)

[30] Hillis WE, Heartwood and Tree Exudates, 100-201, Springer Science & Business Media (2012).