This investigation was devoted to the saturated solubility of 2-acrylamide-2-methylpropanesulfonic acid in 14 pure organic solvents, namely, ethyl acetate, methanol, 1,4-dioxane, ethanol, isopropanol, cyclohexane, n-propanol, ethylene glycol (EG), acetonitrile, acetone, n-butanol, toluene, isobutanol, and n-heptanol gained through the isothermal saturation technique. All determinations were made over a temperature range from 283.15 to 328.15 K under ambient pressure of p = 101.2 kPa. The magnitudes of the mole fraction solubility of 2-acrylamide-2-methylpropanesulfonic acid in the 14 organic solvents increased monotonously as the temperature increased and obeyed the decreasing tendency in different organic solvents: toluene > methanol > ethanol > acetone > n-propanol > n-butanol > n-heptanol > isobutanol > ethyl acetate > EG > isopropanol > 1,4-dioxane > acetonitrile > cyclohexane. The solubility of 2-acrylamide-2-methylpropanesulfonic acid was mathematically correlated using the Apelblat equation and lambda h equation. The maximum magnitudes of the root-mean-square deviation and relative average deviation were, correspondingly, 2488.2 x 10(-6) and 5.59%. On the whole, for a certain solvent, the magnitudes of the relative average deviation attained through the Apelblat equation were smaller than those with the lambda h equation. The obtained solubility and relating thermodynamic studies were invoked as significant data for purification of 2-acrylamide-2-methylpropanesulfonic acid.