Regional air quality models have been used for scientific investigation of trace species dynamics for over two decades and are now beginning to take a central position in air quality management. In particular, they have been used for studying the transport and fate of atmospheric acids, photochemical oxidants (e.g. ozone), and more recently, aerosols. Such models are based on numerically solving the mass conservation equations for a chemically interacting system of species and are applied to horizontal domains of 1000s of kms. Primary applications include assessing the response of pollutant concentrations to emissions controls, quantifying the flux of pollutants across and out of a region, and understanding the impact of specific processes on pollutant concentrations.