The square cyclone separators are widely utilized in CFB boilers to isolate tiny specks from gas flow. In present investigation, three square cyclones are fabricated, after that which is linked in series manner. The average mean particle size of 2.2 mu m (magnesium particles) is utilized in experimental analysis. The estimated collection efficacy of this series arrangement cyclone is 61% at the particle size of 2.2 mu m. It is 10.2% higher than the collection efficiency of single square cyclone. The pressure drop is reduced to 14.3% by this series arrangement configuration. The numerical simulation is executed for predicting the pressure drop for different inlet velocities (10 m/ s to 28 m/s). The assortment efficacy is appraised for the various size of particles through the CFD analysis. The flow pattern effects are arrived for the particle size of 2.2 mu m and 10 mu m. The flow pattern result provides better conformity with experimental results. (c) 2021 Elsevier B.V. All rights reserved.