In the design and preparation of polymer-bonded explosives (PBX), the energetic systems possessing the characteristics of high energy output and low sensitivity are always preferred for researchers. The integration of high explosives and an energetic passivator is considered to be the most useful method in achieving this object. Herein, to explore the effect of 2,4,6-triamino-3,5-dinitropyridine-1-oxide (TANPyO) on the detonation properties and mechanical safety of 1,3,5-trinitro-1,3,5-triazinane (RDX)-based PBX, two methods including direct mixing and crystallization coating were utilized to prepare main explosives, followed by the solvent suspension distillation method to obtain relevant composites. The morphology, mechanical sensitivity, and detonation velocity of as-prepared samples were tested and characterized, as well as armor-piercing ability. Results show that TANPyO plays a positive role in increasing the mechanical safety of RDX-based PBX and is reflected by the 4 %-56 % reduction in explosion probability than that of pure RDX. Moreover, the prepared samples using the crystallization coating method exhibit better performances in detonation velocity and perforation ability than the direct mixing method. These differences reach the peak when the mass ratio of RDX and TANPyO is 1 : 1. In that situation, the reduced values of explosion probability are 20 % (impact sensitivity) and 8 % (friction sensitivity) and the increasing detonation velocity is 309 m . s(-1). These results demonstrate that the integration of TANPyO and the crystallization coating method is a promising way of adjusting the properties of RDX-based PBX.