화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.97, 411-416, May, 2021
DOI10.1016/j.jiec.2021.02.025  Export Citation
High-speed continuous production of polymeric nanoparticles with improved stability using a self-aligned coaxial turbulent jet mixer
Hyeonwoo Han1, Jeong Hoon Yoon2, Gi-Ra Yi2, 3, Won Il Choi4, †, and Jong-Min Lim1, 5, †
  • 1Department of Chemical Engineering, Soonchunhyang University, 22 Soonchunhyang-ro, Shinchang-myeon, Asan-si, Chungcheongnam-do, 31538, Republic of Korea
  • 2Department of Chemical Engineering, Sungkyunkwan University, 2206 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea
  • 3Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro. Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea
  • 4Center for Convergence Bioceramic Materials, Convergence R&D Division, Korea Institute of Ceramic Engineering and Technology, 202, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea
  • 5Department of Electronic Materials and Devices Engineering, Soonchunhyang University, 22 Soonchunhyang-ro, Shinchang-myeon, Asan-si, Chungcheongnam-do, 31538, Republic of Korea
E-mail:,
Continuous synthesis of polymeric nanoparticles (NPs) has been intensively studied due to its great potential to produce NPs with the physicochemical properties of reproducibility and controllability. Here, we developed a self-aligned coaxial turbulent jet mixer for high-speed continuous synthesis of polymeric NPs. The coaxial turbulent jet mixer can be constructed using commercial tube fittings and tubes. Since those fluidic components are self-aligned coaxially, leak-free jet mixers can be assembled without the use of tools or specialized skills in robust manner. Using the jet mixer with polystyrene (PS) solution, uniform polymeric NPs can be synthesized in a fully continuous manner, for which diaphragm pumps and pulsation dampers are used for continuous control of the flow. We also improved the dispersion stability of the PS NPs in aqueous solution against centrifugation by introducing polystyrene-poly (ethylene oxide) diblock copolymer (PS-b-PEO) as steric stabilizer. The NPs prepared using the coaxial turbulent jet mixer were smaller and more uniform in size compared to NPs synthesized by a bulk nanoprecipitation method.
Keywords:Nanoparticles;Nanoprecipitation;Turbulent jet;Mixer;Microfluidics;Steric stabilization
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