화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.99, 187-195, July, 2021
DOI10.1016/j.jiec.2021.04.025  Export Citation
An efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions
Muhammad Asif Hussain1, 2, †, Eun Ju Choi2, Adnan Maqbool1, Muhammad Atif3, Hassan Zeb4, JaeGoo Yeo2, Jung-A Yu2, Yong-Hun Cho2, Moses Noh5, †, and Jung Won Kim2, †
  • 1Department of Metallurgical and Materials Engineering, University of Engineering and Technology, Lahore 39161, Pakistan
  • 2Department of Chemical Engineering, Kangwon National University, Samcheok, Gangwon-do 25913, Republic of Korea
  • 3Department of Chemistry, DS&T, University of Education Lahore (Vehari campus), Punjab, Pakistan
  • 4Institute of Energy and Environment Engineering, University of the Punjab, Lahore, Pakistan
  • 5Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
E-mail:, ,
A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chemistry. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60 °C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulphur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroatomic nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technologically acceptable protocol.
Keywords:Ruthenium;Manganese oxide;Hydration;Water;Nitrile;Amide
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