화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.100, 99-111, August, 2021
DOI10.1016/j.jiec.2021.05.035  Export Citation
Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
Linh Nhat Nguyen1, 2, Neha Kaushik3, Pradeep Bhartiya1, Sintayehu Kebede Gurmessa4, Hwa-Jung Kim4, Liem Quang Nguyen5, Nagendra Kumar Kaushik1, †, and Eun Ha Choi1, †
  • 1Department of Electrical and Biological Physics and Plasma Bioscience Research Centre, Kwangwoon University, Seoul 01897, Republic of Korea
  • 2Laboratory of Plasma Technology, Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi 100000, Viet Nam, Korea
  • 3College of Engineering, Department of Biotechnology, University of Suwon, Hwaseong 18323, Republic of Korea
  • 4Infection Control Convergence Research Center, Department of Microbiology, and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon Republic of Korea
  • 5Laboratory of Plasma Technology, Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi 100000, Viet Nam, Vietnam
E-mail:,
The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on the use of polydopamine-coated gold nanoparticles (Au@PDA NPs) that showed excellent selectivity towards cancer cells. The Au@PDA NPs were prepared by a plasma synthesis method with a short reaction time and minimize the use of chemicals. Prominently, Au@PDA NPs not only exhibited high cellular internalization but also stimulated immunogenic cell death (ICD) in aggressive breast carcinoma cells. Moreover, it was observed that damage-associated molecular patterns (DAMPs) were released by damaged cells together with the autophagy process after Au@PDA NPs exposure, which acted as endogenous danger signals to regulate the consequent immune response. This study highlights the novel mechanism of Au@PDA NPs-triggered anti-tumor immunity against immunosuppressive cancers, demonstrated the potential of the Au@PDA NPs for cancer immunotherapy.
Keywords:Cold plasma synthesis;Gold nanoparticles;Breast carcinoma cells;Autophagy;Immunogenic cell death
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