강화 단계가 PLA 매트릭스 나노 복합재의 기계적 및 생체 적합성 특성에 미치는 영향

Hatice Evlen; Gulcin Erel

Polymer(Korea), Vol.45, No.4, 491-500, July, 2021

DOI10.7317/pk.2021.45.4.491 Export Citation

강화 단계가 PLA 매트릭스 나노 복합재의 기계적 및 생체 적합성 특성에 미치는 영향

Effect of the Reinforcement Phase on the Mechanical and Biocompatibility Properties of PLA Matrix Nano Composites

Hatice Evlen^†, and Gulcin Erel^{1, †}

Industrial Design Engineering Department, Technology Faculty, Karabuk University, 78100, Turkey
¹Industrial Design Engineering Department, Graduate Education Institute, Karabuk University, 78100, Turkey

E-mail:,

In this study, it was aimed to obtain nanocomposite structure with poly(lactic acid) (PLA) matrix and to improve the mechanical and morphological properties of the PLA matrix nano-reinforced composites. Titanium dioxide (TiO2) and hydroxyapatite (HA) nanoparticles were used as reinforcing elements. Solvent casting particle leaching method was used for the production of the composites. Thermal characterization and compression test of the composite samples were carried out. Microstructural properties and the phases formed on the surface of in vitro tested samples were examined. As a result of the study, it was observed that nano-reinforced composites with PLA matrix are biocompatible and apatite formation increases gradually every week. Also the highest compressive strength was obtained in PLA/HA samples, while the lowest was obtained in PLA sample. It was concluded that composites prepared within the scope of the study can be used as artificial tissue scaffolds in biomedical and medical applications.

Keywords:poly(lactic acid);hydroxiapatite;titanium dioxide;biocompatibility;nano composite;tissue scaffold

[References]

Dursun S, Erkan N, Yesiltas M, J. of Fish Sci., 4, 50 (2010)
Henton DE, Gruber P, Lunt J, Randall J, In Natural Fibers, Biopolymers, And Biocomposites, pp 527, 2005.
Nehal S, Mohamed A, Mohamed G, Sahar E, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 108, 1 (2020)
de Almeida JFM, da Silva ALN, Escocio VA, da Silva AHMDT, de Sousa AMF, Nascimento CR, Bertolino LC, Polym. Bull., 73(12), 3531 (2016)
Costa RGF, Brichi GS, Ribeiro C, Mattoso LHC, Polym. Bull., 73(11), 2973 (2016)
Kothapalli CR, Shaw MT, Wei M, Acta Biomater., 1, 653 (2005)
Watazu A, Kamiya A, Zhu J, Nonami T, Sonoda T, Shi W, Naganuma K, Key Eng. Mater., 240, 931 (2003)
Kretlow JD, Young S, Klouda L, Wong M, Mikos AG, Adv. Mater., 21(32-33), 3368 (2009)
Nazhat SN, Kellomaki M, Tormala P, Tanner KE, Bonfield W, J. Bio. Mater. Res., 58, 335 (2001)
Senatov FS, Niaza KV, Zadorozhnyy MY, Maksimkin AV, Kaloshkin SD, Estrin YZ, J. Mech. Behav. Biomed. Mater., 57, 139 (2016)
Talal A, McKay IJ, Tanner KE, Hughes FJ, J. Mater. Sci: Mater. Med., 24, 2211 (2013)
Demirkol N, Acta Phys. Polonica A, 132, 786 (2017)
Wei G, Ma PX, Biomater, 25, 4749 (2004)
Tanodekaew S, Channasanon S, Kaewkong P, Uppanan P, Proced. Eng., 59, 144 (2013)
Mao D, Li Q, Bai N, Dong H, Li D, Carbohydr. Polym., 180, 104 (2018)
Lu X, Lv X, Sun Z, Zheng Y, Eur. Polym. J., 44, 2476 (2008)
Khulbe KC, Matsuura T, Feng C, In Handbook of Polymers for Pharmaceutical Technologies, p.43, 2015.
Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR, Biomaterials, 27, 3413 (2006)
Wu D, Spanou A, Diez-Escudero A, Persson C, J. Mech. Behav. Biomed. Mater., 103608 2020.
Evlen H, Erel G, Biomaten 2018 Abstract Booklet; Ankara, Turkey; p.89, 2018.
Buzarovska A, Gualandi C, Parrilli A, Scandola M, Composites Part B, 81, 189 (2015)
Li Y, Chen C, Li J, Sun XS, Polymer, 2367, 2011
Kodal M, Sirin H, Ozkoc G, Polym. Eng. Sci., 54(2), 264 (2014)
Callister WD, Rethwisch RD, Fundamentals of Material Science and Engineering, 8th ed.; Wiley: New York, USA, 2009.
Kawakami K, In Handbook of Thermal Analysis and Calorimetry; Amsterdam, Netherland, pp.613, 2018.
Salerno A, Fernandez-Gutierrez M, San Roman J, Domingo CR, Royal Soc. of Chem., 4, 61491 (2014).

[1] Dursun S, Erkan N, Yesiltas M, J. of Fish Sci., 4, 50 (2010)

[2] Henton DE, Gruber P, Lunt J, Randall J, In Natural Fibers, Biopolymers, And Biocomposites, pp 527, 2005.

[3] Nehal S, Mohamed A, Mohamed G, Sahar E, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 108, 1 (2020)

[4] de Almeida JFM, da Silva ALN, Escocio VA, da Silva AHMDT, de Sousa AMF, Nascimento CR, Bertolino LC, Polym. Bull., 73(12), 3531 (2016)

[5] Costa RGF, Brichi GS, Ribeiro C, Mattoso LHC, Polym. Bull., 73(11), 2973 (2016)

[6] Kothapalli CR, Shaw MT, Wei M, Acta Biomater., 1, 653 (2005)

[7] Watazu A, Kamiya A, Zhu J, Nonami T, Sonoda T, Shi W, Naganuma K, Key Eng. Mater., 240, 931 (2003)

[8] Kretlow JD, Young S, Klouda L, Wong M, Mikos AG, Adv. Mater., 21(32-33), 3368 (2009)

[9] Nazhat SN, Kellomaki M, Tormala P, Tanner KE, Bonfield W, J. Bio. Mater. Res., 58, 335 (2001)

[10] Senatov FS, Niaza KV, Zadorozhnyy MY, Maksimkin AV, Kaloshkin SD, Estrin YZ, J. Mech. Behav. Biomed. Mater., 57, 139 (2016)

[11] Talal A, McKay IJ, Tanner KE, Hughes FJ, J. Mater. Sci: Mater. Med., 24, 2211 (2013)

[12] Demirkol N, Acta Phys. Polonica A, 132, 786 (2017)

[13] Wei G, Ma PX, Biomater, 25, 4749 (2004)

[14] Tanodekaew S, Channasanon S, Kaewkong P, Uppanan P, Proced. Eng., 59, 144 (2013)

[15] Mao D, Li Q, Bai N, Dong H, Li D, Carbohydr. Polym., 180, 104 (2018)

[16] Lu X, Lv X, Sun Z, Zheng Y, Eur. Polym. J., 44, 2476 (2008)

[17] Khulbe KC, Matsuura T, Feng C, In Handbook of Polymers for Pharmaceutical Technologies, p.43, 2015.

[18] Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR, Biomaterials, 27, 3413 (2006)

[19] Wu D, Spanou A, Diez-Escudero A, Persson C, J. Mech. Behav. Biomed. Mater., 103608 2020.

[20] Evlen H, Erel G, Biomaten 2018 Abstract Booklet; Ankara, Turkey; p.89, 2018.

[21] Buzarovska A, Gualandi C, Parrilli A, Scandola M, Composites Part B, 81, 189 (2015)

[22] Li Y, Chen C, Li J, Sun XS, Polymer, 2367, 2011

[23] Kodal M, Sirin H, Ozkoc G, Polym. Eng. Sci., 54(2), 264 (2014)

[24] Callister WD, Rethwisch RD, Fundamentals of Material Science and Engineering, 8th ed.; Wiley: New York, USA, 2009.

[25] Kawakami K, In Handbook of Thermal Analysis and Calorimetry; Amsterdam, Netherland, pp.613, 2018.

[26] Salerno A, Fernandez-Gutierrez M, San Roman J, Domingo CR, Royal Soc. of Chem., 4, 61491 (2014).