화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Chemical Engineering Research, Vol.59, No.3, 455-466, August, 2021
DOI10.9713/kcer.2021.59.3.455  Export Citation
Experimental Investigation on Finasteride Microparticles Formation via Gas Antisolvent Process
Mohammad Najafi, Nadia Esfandiari†, Bizhan Honarvar, and Zahra Arab Aboosadi
  • Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
E-mail:
Micro and nanoparticles of Finasteride were prepared by gas-antisolvent method. The influence of process parameters such as pressure (100, 130 and 160 bar), temperature (308, 318 and 328 K) and solute concentrations (10, 25 and 40 mg/ml) on mean particle size was studied by Box-Behnken design. As ANOVA results indicated, the highest influence in production of smaller particles was attributed to the pressure. Optimum condition leading to the smallest particle size was as follows: initial solute concentration, 10 mg/ml; temperature, 308 K and pressure, 160 bar. The particles were evaluated with FTIR, SEM, DLS, XRD as well as DSC. The analyses revealed a size decrease in the precipitated Finasteride particles (232.4 nm, on mean) via gas-antisolvent method, as compared to the original particles (55.6 μm).
Keywords:Response surface methodology;Supercritical fluid technology;Dimethyl sulfoxide;Finasteride;Nanoparticle
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