화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.102, 343-350, October, 2021
DOI10.1016/j.jiec.2021.07.023  Export Citation
Cellulose nanofibrils composite hydrogel with polydopamine@zeolitic imidazolate framework-8 encapsulated in used as efficient vehicles for controlled drug release
Yingying Liu1, 2, †, Ying Huo1, Qing Fan3, Mei Li1, Hongbin Liu1, †, Bin Li2, †, and Youming Li4
  • 1Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, Tianjin 300457, China
  • 2CAS Key Laboratory of Bio-Based Material, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China
  • 3Qingdao University, Qingdao 266071, China
  • 4State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
E-mail:, ,
Herein, we report a nanocellulose hydrogel that has a packaging structure for on-demand drug release. Zeolitic imidazolate frameworks-8 (ZIF-8) were grown on the surface of polydopamine (PDA) to produce PDA@ZIF-8 nanoparticles. The obtained PDA@ZIF-8 nanoparticles were then incorporated into a network of cellulose nanofibrils (CNFs) to fabricate a PDA@ZIF-8/CNFs composite hydrogel. The loading ratio of the drug tetracycline hydrochloride (TH) was 58%. A slight burst release behavior was observed at the beginning, and the composite hydrogel presented a significant pH-dependent release behavior. The drug delivery time of the PDA@ZIF-8/CNFs composite hydrogel was 3.5 times longer than that of the PDA/CNFs composite hydrogel. Furthermore, NIR light radiation accelerated the drug delivery rate. The drug release mechanism was mainly driven by anomalous transport. Importantly, the novel PDA@ZIF-8/CNFs composite hydrogel was found to be biocompatible according to in vitro cytotoxicity test. Because of its unique multiple drug release responses, the PDA@ZIF-8/CNFs composite hydrogel may be used in future clinical applications as a promising drug delivery carrier.
Keywords:Nanocellulose;Hydrogels;Drug delivery;Zeolitic imidazolate frameworks-8;Polydopamine
  1. Xue Y, Mou Z, Xiao H, Nanoscale, 9, 14758 (2017)
  2. Zhu HL, Luo W, Ciesielski PN, Fang ZQ, Zhu JY, Henriksson G, Himmel ME, Hu LB, Chem. Rev., 116(16), 9305 (2016)
  3. Thomas B, Raj MC, Athira KB, Rubiyah MH, Joy J, Moores A, Drisko GL, Sanchez C, Chem. Rev., 118(24), 11575 (2018)
  4. Datta LP, Manchineella S, Govindaraju T, Biomaterials, 230 (2020)
  5. Salimi S, Sotudeh-Gharebagh R, Zarghami R, Chan SY, Yuen KH, ACS Sustain. Chem. Eng., 7, 15800 (2019)
  6. Shen X, Shamshina JL, Berton P, Gurau G, Rogers RD, Green. Chem., 18, 53 (2016)
  7. Mertaniemi H, Escobedo-Lucea C, Sanz-Garcia A, Gandia C, Makitie A, Partanen J, Ikkala O, Yliperttula M, Biomaterials, 82, 208 (2016)
  8. Hai J, Zeng X, Zhu Y, Wang B, Biomaterials, 194, 161 (2019)
  9. Trovatti E, Silva NHCS, Duarte IF, Rosado CF, Almeida IF, Costa P, Freire CSR, Silvestre AJD, Neto CP, Biomacromolecules, 12(11), 4162 (2011)
  10. Trovatti E, Freire CSR, Pinto PC, Almeida IF, Costa P, Silvestre AJD, Neto CP, Rosado C, Int. J. Pharmaceut, 435, 83 (2012)
  11. Fiorati A, Negrini NC, Baschenis E, et al., Materials, 13, 183 (2020)
  12. Masruchin N, Park B, Causin V, Cellulose, 25, 485 (2018)
  13. Zhang H, Yang C, Zhou WJ, Luan Q, Li WL, Deng QC, Dong X, Tang H, Huang FH, ACS. Sustain, Chem. Eng., 6, 13924 (2018)
  14. Liu J, Dong J, Zhang T, Peng Q, J. Control. Release, 286, 64 (2018)
  15. Liu YL, Ai KL, Lu LH, Chem. Rev., 114(9), 5057 (2014)
  16. Cai W, Gao HY, Chu CC, Wang XY, WangJQ, Zhang PF, Lin G, Li WG, Liu G, Chen XY, ACS Appl. Mater Interfaces, 9, 2040 (2017)
  17. Lynge ME, van der Westen R, Postma A, Stdler B, Nanoscale, 3, 4916 (2011)
  18. Liu YL, Ai KL, Liu JH, Deng M, He YY, Lu LH, Adv. Mater., 25(9), 1353 (2013)
  19. Han L, zhang YN, Lu X, Wang KF, Wang ZM, Zhang HP, ACS. Appl. Mater. Interfaces, 8, 29088 (2016)
  20. Liu YY, Sui YL, Liu C, Liu CQ, Wu MY, Li B, Li YM, Carbohydr. Polym., 188, 27 (2018)
  21. Mihai M, Racovita S, Vasiliu A, Doroftei F, Barbu-Mic C, Schwarz S, Steinbach C, Simon F, ACS. Appl. Mater. Inter., 9, 37264 (2017)
  22. Liang Y, Zhao X, Hu T, Chen B, Yin Z, Ma PX, Guo BL, Small, 15, 190004 (2019)
  23. Deng X, Liang S, Cai X, Huang S, Cheng Z, Shi Y, Pang ML, Ma P, Lin J, Nano Lett., 19, 6772 (2019)
  24. Wang PL, Xie LH, Joseph EA, Li JR, Su XO, Zhou HC, Chem. Rev., 119(18), 10638 (2019)
  25. Ricco R, Liang W, Li S, Gassensmith JJ, Caruso F, Doonan C, Falcaro P, ACS Nano, 12, 13 (2018)
  26. Salunkhe RR, Kaneti YV, Yamauchi Y, ACS Nano., 11, 5293 (2017)
  27. Erucar I, Keskin S, Ind. Eng. Chem. Res., 55(7), 1929 (2016)
  28. Wu MX, Yang YW, Adv. Mater., 29, 160613 (2017)
  29. Zhuang J, Kuo C, Chou L, Liu D, Weerapana E, Tsung C, ACS. Nano., 8, 2812 (2014)
  30. Silva JSF, Silva JYR, de Sa GF, Araujo SS, Filho MAG, Ronconi CM, Santos TC, Junior SA, ACS Omega, 3, 12147 (2018)
  31. Zhang H, Chen W, Gong K, Chen J, ACS. Appl. Mater. Inter., 9, 31519 (2017)
  32. Wu Q, Niu M, Chen X, Tan L, Fu C, Ren X, Ren J, Li LF, Xu K, Zhong HG, Meng XW, Biomaterials, 162, 132 (2018)
  33. Zheng HQ, Zhang YN, Liu LF, Wan W, Guo P, Nystrom AM, Zou XD, J. Am. Chem. Soc., 138(3), 962 (2016)
  34. Hong S, Na YS, Choi S, Song IT, Kim WY, Lee H, Adv. Funct. Mater., 22(22), 4711 (2012)
  35. Li SN, Zhang LY, Liang X, Wang TT, Chen XJ, Liu CM, Li L, Wang CG, Chem. Eng. J., 378, 122178 (2019)
  36. Liu YY, Wang QB, Shen Q, Wu MY, Liu C, Zhang YD, Li B, Li YM, Chemistryselect, 3, 6852 (2018)
  37. Zhang J, Chen PC, Yuan BK, Ji W, Cheng ZH, Qiu XH, Science, 342(6158), 611 (2013)
  38. Zhang X, Liu LZ, Huang LJ, Zhang WT, Wang R, Yue TL, Sun J, Li GL, Wang JL, Nanoscale, 11, 9468 (2019)
  39. Zhu LT, Zong L, Wu XC, Li MJ, Wang HS, You J, Li CX, ACS. Nano., 12, 4462 (2018)
  40. Ranjbar-Mohammadi M, Zamani M, Prabhakaran MP, Bahrami SH, Ramakrishna S, Mat. Sci. Eng: C, 58, 521 (2016)
  41. Wang X, Wang C, Wang X, Wang Y, Zhang Q, Cheng Y, Chem. Mater., 29, 1370 (2017)
  42. Zhuang J, Kuo CH, Chou LY, Liu DY, Weerapana E, Tsung CK, ACS. Nano., 8, 2812 (2014)
  43. Nam HS, An J, Chung DJ, Kim JH, Chung CP, Macromol. Res., 14(5), 530 (2006)
  44. Pandey SK, Patel DK, Maurya AK, Thakur R, Mishra DP, Vinayak M, Haldara C, Maiti P, Int. J. Biol. Macromol., 89, 99 (2016)
  45. Singh B, Chauhan GS, Sharma DK, Chauhan N, Carbohydr. Polym., 67, 559 (2007)
  46. Siepmann J, Peppas NA, Adv. Drug. Deliv. Rev., 64, 163 (2012)