Porous Zn(II)-Organic Framework with Tetrazolyl Decorated Pores for Selective C2H2 Adsorption and Treatment Activity on Infantile Meningitis

Yang Yu; Qi-Gai Yin; Li-Jing Ye; Hui Yu

Macromolecular Research, Vol.29, No.9, 605-612, September, 2021

DOI10.1007/s13233-021-9071-y Export Citation

Porous Zn(II)-Organic Framework with Tetrazolyl Decorated Pores for Selective C2H2 Adsorption and Treatment Activity on Infantile Meningitis

Yang Yu, Qi-Gai Yin^†, Li-Jing Ye¹, and Hui Yu¹

Department of Neonatology, The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, P. R. China
¹Department of Medicine, Fudan University, Shanghai, P. R. China

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Via applying a dual-functional tetrazolyl-carboxylic ligand 5-(1H-tetrazole- 5-yl)-1,3-bis(3,5-dicarboxylphenyl)-benzene (H5TBDPB), a new Zn(II)-containing metalorganic framework (MOF) with the chemical composition of [Zn6(HTBDPB)3(H2O)6]. 9DMF.15H2O (1) has been successfully prepared. This article methodically explored the gas sorption characteristics of activated 1 for C2H2, CO2, and CH4, and it holds a relative large C2H2 sorption capacity of 164.0 cm3 (STP) g-1 at 298 K and 1 bar with the C2H2/CH4 and C2H2/CO2 sorption selectivity of 34.8 and 4.6 at 298 K, respectively, revealing its potential application for the selective C2H2 adsorption. Additionally, we studied its application value on the infantile meningitis as well as the related mechanism was evaluated. The results of the bacteria growth curve automatic analysis indicated the compound could decrease the growth of Streptococcus meningitidis bacteria. Besides, the compound could also inhibit the survival genes expression in Streptococcus meningitidis in a dose-dependent manner. Molecular docking simulation has revealed that the carboxyl groups are the donor for the formed hydrogen bonds, while the tetrazole groups are the acceptor for the formed hydrogen bonds, such features make the Zn complex as an attractive candidate for infantile meningitis treatment.

Keywords:metal-organic framework (MOF);gas adsorption;infantile meningitis;molecular docking

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[2] Geiseler PJ, Nelson KE, Levin S, Reddi KT, Moses VK, Rev. Infect. Dis., 2, 725 (1980)

[3] Schobert H, Chem. Rev., 114(3), 1743 (2014)

[4] Li JX, Du ZX, J. Clust. Sci., 31, 507 (2020)

[5] Li JX, Du ZX, Xiong LY, Fu LL, Bo WB, J. Solid State Chem., 293, 121799 (2021)

[6] Feng X, Feng YQ, Liu L, Wang LY, Song HL, Ng SW, Dalt. Trans., 42, 7741 (2013)

[7] Hu ML, Mohammad YM, Morsali A, Coord. Chem. Rev., 387, 415 (2019)

[8] Hu ML, Safarifard V, Doustkhah E, Rostamnia S, Morsali A, Nouruzi N, Beheshti S, Akhbari K, Microporous Mesoporous Mater., 256, 111 (2018)

[9] He H, Hashemi L, Hu ML, Morsali A, Coord. Chem. Rev., 376, 319 (2018)

[10] Li H, Wang T, Pan W, Wang M, Chai C, Chen P, Wang J, Wang J, IEEE Access, 9, 28076 (2021)

[11] Duan C, Yu Y, Li J, Li L, Huang B, Chen D, Xi H, Sci. China Mater., 64, 1305 (2021)

[12] Liu K, Ma D, Li B, Li Y, Yao K, Zhang Z, Han Y, Shi Z, J. Mater. Chem. A, 2, 15823 (2014)

[13] Rao X, Cai J, Yu J, He Y, Wu C, Zhou W, Yildirim T, Chen B, Qian G, Chem. Commun., 49, 6719 (2013)

[14] Luo F, Yan CS, Dang LL, Krishna R, Zhou W, Wu H, Dong XL, Han Y, Hu TL, O'Keeffe M, Wang LL, Luo MB, Lin RB, Chen BL, J. Am. Chem. Soc., 138(17), 5678 (2016)

[15] Zeng H, Xie M, Huang Y, Zhao Y, Xie X, Bai J, Wan M, Krishna R, Lu W, Li D, Angew. Chem.-Int. Edit., 58, 8515 (2019)

[16] Wu HQ, Yan CS, Luo F, Krishna R, Inorg. Chem., 57(7), 3679 (2018)

[17] Wang X, Wang X, Zhang X, Fan W, Li Q, Jiang W, Dai F, Sun D, Cryst. Growth Des., 20, 5670 (2020)

[18] d’Angelo J, Morgant G, Ghermani NE, Desmaele D, Fraisse B, et al., Polyhedron, 27, 537 (2008)

[19] Abu-Dief AM, El-Sagher HM, Shehata MR, Appl. Organomet. Chem., 33, 537 (2019)

[20] Zhou QD, Hambley TW, Kennedy BJ, Lay PA, Turner P, Warwick B, Biffin JR, Regtop HL, Inorg. Chem., 39(17), 3742 (2000)

[21] Tarushi A, Totta X, Papadopoulos A, Kljun J, Turel I, Kessissoglou DP, Psomas G, Eur. J. Med. Chem., 74, 187 (2014)

[22] Nakano MM, Lin A, Zuber CS, Newberry KJ, Brennan RG, Zuber P, PLoS One, 5, e8664 (2010)

[23] Li Y, Wang G, Yang H, Hou L, Wang Y, Zhu Z, Chem.-A Eur. J., 26, 16402 (2020)

[24] Lin S, Fan L, Zhou P, Xu T, Jiang Z, Hu S, Chen J, He Y, Eur. J. Inorg. Chem., 2021, 2070 (2021)

[25] Li H, Bonduris H, Zhang X, Ye Y, Alsalme A, Lin RB, Zhang Z, Xiang S, Chen B, J. Solid State Chem., 284, 121209 (2020)

[26] Duan X, Lv R, Li S, Tang J, Ge J, Zhao D, Z. Anorg. Allg. Chem., 645, 955 (2019)

[27] Zhang Z, Peh SB, Wang Y, Kang C, Fan W, Zhao D, Angew. Chem.-Int. Edit., 59, 18927 (2020)