화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.103, 165-174, November, 2021
DOI10.1016/j.jiec.2021.07.030  Export Citation
Organobase assisted synthesis of Co(OH)2 nanosheets enriched with oxygen vacancies for nonenzymatic glucose sensing at physiological pH
Muhammad Adeel1, 2, Vincenzo Canzonieri3, 4, Salvatore Daniele2, †, Flavio Rizzolio2, 3, †, and Md. Mahbubur Rahman5, †
  • 1PhD School in Science and Technology of Bio and Nanomaterials, University Ca’Foscari of Venice, Venice, Italy
  • 2Department of Molecular Sciences and Nanosystems, Ca’Foscari University of Venice, 30123 Venezia, Italy
  • 3Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy
  • 4Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy
  • 5Department of Applied Chemistry, Konkuk University, Chungju 27478, Republic of Korea
E-mail:, ,
Herein, a two-dimensional (2D) Co(OH)2 nanosheet (NS) was prepared by reacting Co(II) acetate with 2- ethylimidazole and trimethylamine at room temperature. The as-prepared Co(OH)2 NS-modified screenprinted electrode enabled glucose sensing in human blood plasma samples (HBP) diluted with phosphate buffer saline (PBS, pH 7.4) and NaOH (0.1 M, pH 13.0) solutions. The electrocatalytic activity of Co(OH)2 NS for glucose oxidation in a wide pH range can be ascribed to the enriched oxygen vacancies with a high surface area of the porous NS, which enabled the facile formation of CoII/CoIII redox pair. The oxidation current response as a function of glucose concentration displayed two straight lines in the ranges 55.12-117.50 μM and 180-12055 μM in PBS diluted HBP, and 62.80-180 μM and 305-12055 μM in NaOH diluted HBP with the sensitivity of 430 and 98.18 μA/cm2/mM and the limit of detection of 0.082 and 2.2 lM, in PBS and NaOH diluted HBP solutions, respectively. The sensor also exhibited good long-term stability, repeatability, and interference-free signals. The good analytical performance of the proposed sensor demonstrates the suitability of Co(OH)2 NS as a material to fabricate disposable systems for the direct detection of glucose in human body fluids at physiological pH.
Keywords:Cobalt hydroxide;Oxygen vacancies;Electrochemical;Enzymeless glucose sensing;Screen-printed electrodes
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