Ordered mesoporous MgAl2O4 support was synthesized by one-pot evaporation-induced self-assembly method with block copolymers. Nanocomposite catalysts were prepared by loading this support with PrNi0.9Ru0.1O3 perovskite or Ni + Ru-doped Ce0.35Zr0.35Pr0.3O2 fluorite oxides. Their texture, structure, surface properties and reactivity have been studied by combination of modern structural, spectroscopic and kinetic methods. Suppression of MgAl2O4 support acidity, strong interaction of small Ru-Ni alloy nanoparticles with the surface layers of this support modified by perovskite and fluorite oxides with a high oxygen mobility and reactivity provide a high activity and stability to coking and sintering of these catalysts in all studied reactions of methane and ethanol transformation into syngas. Ni + Ru/Ce0.35Zr0.35Pr0.3O2/MgAl2O4 active component loaded on honeycomb Fechraloy foil substrate demonstrated a high performance and stability to coking in autothermal natural gas oxi-dry reforming, ethanol steam reforming and autothermal reforming of ethyl acetate in concentrated feeds promising for the practical application.