Utilization of biomass into liquid fuels and chemicals will be reduce the dependency on fossil-based resources and CO2 emissions. In this work, we report a series of copper (loadings 5-20 wt.%) supported on calcined Mg9Al2.7-Ga2.3O2 (Ga2.3-HT) catalysts were prepared by a wetness impregnation method and their catalytic performance was investigated for the production of 1,2-propanediol from glycerol in a vapor phase. The physicochemical properties of the these catalysts were characterized by X-ray diffraction (XRD), N2 adsorption (BET), Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Elemental mapping, UV-vis diffused reflectance spectroscopy (UV-DRS), CO2-Temperature programmed desorption (CO2-TPD), N2O chemisorption and temperature programmed reduction (TPR) analysis. These results demonstrated that Ga promotional effects observed to be significant over the Ga2.3-HT support and that influenced the final Cu based catalysts. Moreover, Cu functioning is found to be a vital role for achieved high catalytic activity in glycerol hydrogenolysis. Lower Cu loading is a more active and selective to the 1,2-PrDs production due to highly dispersed particles, and distributed homogeneously along with enough number of basic sites and acido-basic sites. The catalytic activity of calcined 5CuO/Ga2.3-HT was systematically investigated under varying reaction parameters including copper loading, various Mg/Al/Ga ratios, reaction temperature, hydrogen flow rate, glycerol concentration and weight hourly space velocity to derive the optimum conditions for the reaction. The catalyst stability, reusability and structure-activity correlation were also elucidated.